![]() Minimizing treatment-induced emergence of antibiotic resistance in bacterial infections. Strain-level characterization of broad host range mobile genetic elements transferring antibiotic resistance from the human microbiome. Epidemiology of plasmid lineages mediating the spread of extended-spectrum beta-lactamases among clinical Escherichia coli. Antibiotic perturbation of the preterm infant gut microbiome and resistome. Functional characterization of the antibiotic resistance reservoir in the human microflora. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. eLife (2018).Īntimicrobial Resistance Collaborators. The distribution of antibiotic use and its association with antibiotic resistance. A review of the role of antibiotic policies in the control of antibiotic resistance. Global increase and geographic convergence in antibiotic consumption between 20. Antibiotics as instigators of microbial dysbiosis: implications for asthma and allergy. Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice. This study highlights an underexplored area in identifying antibiotic-induced microbiome perturbation as a contributor to intestinal graft-versus-host disease. Mucus-degrading Bacteroides link carbapenems to aggravated graft-versus-host disease. The gut microbiome as a reservoir for antimicrobial resistance. Centers for Disease Control and Prevention (2019).Īnthony, W. Antibiotic resistance threats in the United States. mSphere (2021).Ĭenters for Disease Control and Prevention. Gram negative bacteria antibiotics trial#Randomized controlled trial of oral vancomycin treatment in Clostridioides difficile-colonized patients. Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens. Centers for Disease Control and Prevention (2021). 14, 56–57 (2016).Ĭenters for Disease Control and Prevention. On the antibacterial action of cultures of a penicillium, with special reference to their use in the isolation of B. Clinical relevance of macrolide-resistant Streptococcus pneumoniae for community-acquired pneumonia. Maternal antibiotic exposure during pregnancy is a risk factor for community-acquired urinary tract infection caused by extended-spectrum beta-lactamase-producing bacteria in infants. Epidemics of diarrhea caused by a clindamycin-resistant strain of Clostridium difficile in four hospitals. Rising incidence of early-onset colorectal cancer - a call to action. Role of microbiome in carcinogenesis process and epigenetic regulation of colorectal cancer. ![]() Antibiotic use and the development of inflammatory bowel disease: a national case-control study in Sweden. Host–bacterial mutualism in the human intestine. Current understanding of the human microbiome. The gut microbiota in the first decade of life. Human gut microbiota/microbiome in health and diseases: a review. Finally, we provide a synopsis of available strategies to minimize antibiotic-induced damage or to restore the pretreatment architectures of the gut microbial community. ![]() We present an overview of the currently complex picture of treatment-induced changes to the microbial community and highlight essential considerations for future investigations of antibiotic-specific outcomes. In this Review, we discuss factors that influence restructuring of the gut microbiome on antibiotic exposure. With the advent of multi-omic approaches for systems-level profiling of microbial communities, we are beginning to identify microbiome-intrinsic and microbiome-extrinsic factors that affect microbiome dynamics during antibiotic exposure and subsequent recovery. Yet, as the gut microbiome is a complex ecological network of microorganisms, the effects of antibiotics can be highly variable. Antibiotic-mediated perturbation of the gut microbiome is associated with numerous infectious and autoimmune diseases of the gastrointestinal tract. ![]()
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